The Polyclonal Hypothesis Of Cancer Origin: From Field Injury to Functional Monoclonality in Cancer Origin

A paradigm-challenging concept paper proposing that cancer often originates from multiple independently transformed clones within a shared tissue field, with clonal dominance emerging through ecological selection rather than single-cell origin.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-31
DOI
https://doi.org/10.5281/zenodo.17329552
Primary Topic
Advanced Proteomics Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

The Polyclonal Hypothesis Of Cancer Origin: From Field Injury to Functional Monoclonality in Cancer Origin

Zenodo (CERN European Organization for Nuclear Research)
Advanced Proteomics Techniques and Applications
article

The Polyclonal Hypothesis Of Cancer Origin: From Field Injury to Functional Monoclonality in Cancer Origin

article en

Abstract

A paradigm-challenging concept paper proposing that cancer often originates from multiple independently transformed clones within a shared tissue field, with clonal dominance emerging through ecological selection rather than single-cell origin.

Zenodo (CERN European Organization for Nuclear Research)
University of Nairobi (KE)
Life in Land
Openalex Percentile: Top 51%
Advanced Proteomics Techniques and Applications
DOIOpen Access PDFOpenAlex
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