Enhanced Nanopore Sequencing Analysis via Hyperdimensional Embedding and Recursive Causal Inference (HENCRI)

**Abstract:** This paper introduces Hyperdimensional Embedding and Recursive Causal Inference (HENCRI), a novel framework for significantly improving accuracy and throughput in nanopore sequencing data analysis. Leveraging hyperdimensional vector spaces for nucleotide representation and a recursive causal inference engine for signal denoising and error correction, HENCRI achieves a 1.5x improvement in base calling accuracy and a 2.0x speedup in processing time compared to state-of-the-art methods. The system's self-optimizing architecture incorporates a human-AI feedback loop for continual improvement, demonstrating immediate commercial viability and paving the way for scalable, real-time genome sequencing.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-11
DOI
https://doi.org/10.5281/zenodo.17329434
Primary Topic
Nanopore and Nanochannel Transport Studies
Type
article
Field-Weighted Citation Impact
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article

Enhanced Nanopore Sequencing Analysis via Hyperdimensional Embedding and Recursive Causal Inference (HENCRI)

Zenodo (CERN European Organization for Nuclear Research)
Nanopore and Nanochannel Transport Studies
article

Enhanced Nanopore Sequencing Analysis via Hyperdimensional Embedding and Recursive Causal Inference (HENCRI)

article en

Abstract

**Abstract:** This paper introduces Hyperdimensional Embedding and Recursive Causal Inference (HENCRI), a novel framework for significantly improving accuracy and throughput in nanopore sequencing data analysis. Leveraging hyperdimensional vector spaces for nucleotide representation and a recursive causal inference engine for signal denoising and error correction, HENCRI achieves a 1.5x improvement in base calling accuracy and a 2.0x speedup in processing time compared to state-of-the-art methods. The system's self-optimizing architecture incorporates a human-AI feedback loop for continual improvement, demonstrating immediate commercial viability and paving the way for scalable, real-time genome sequencing.

Zenodo (CERN European Organization for Nuclear Research)
Freed–Hardeman University (US)
Openalex Percentile: Top 51%
Nanopore and Nanochannel Transport Studies
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