Synthesis of GG‐ <i>g</i> ‐P(NIPAM)/CoFe ₂ O ₄ Composite Hydrogels as a Drug Delivery Device for Metformin Hydrochloride

Abstract The gum–ghatti (GG) modified hydrogel was prepared. The hydrogel GG‐g‐P(NIPAM)/CoFe 2 O 4 (GGNIPACF) was prepared by using free‐radical KPS initiator and MBA as a cross‐linker agent and in situ loading with CoFe 2 O 4 nanoparticles. The prepared materials were characterized by FT‐IR, XRD, and TGA. The drug release profile of metformin was studied in different pH media using bare hydrogels GGNIPACF‐0 and GGNIPACF‐3. The drug release study of metformin indicated that both materials showed high releasing profile at acidic pH via Fickian diffusion mechanism.