Prevalence of Folate Deficiency in Patients with Depressive Symptoms: Biochemical and Clinical Implications

Objective: To evaluate the prevalence of folate deficiency in patients presenting with depressive symptoms and to explore associated biochemical abnormalities and clinical implications. Methods: Observational study analyzing serum folate, vitamin B12, ferritin, thyroid function, and homocysteine levels in patients with depressive symptoms. Results: Folate deficiency was prevalent in a significant subset of patients and was frequently associated with vitamin B12 deficiency, iron deficiency, and thyroid dysfunction. Conclusion: Folate deficiency is a common and potentially modifiable factor in depression, underscoring the need for routine biochemical screening in psychiatric care.