Intralesional Candida Antigen Immunotherapy for Refractory Molluscum Contagiosum in an Immunocompetent Adult

Molluscum contagiosum is a poxvirus-induced skin infection that typically resolves spontaneously but may persist and become refractory in adults. We report a 38-year-old immunocompetent male with over 40 lesions on the trunk, forearms, and pubic region, persisting for 18 months despite cryotherapy, topical potassium hydroxide, and curettage. Intralesional Candida antigen was injected into three representative lesions every three weeks for four sessions. Regression occurred in both injected and non-injected lesions, with complete clearance by week 12 and no recurrence during 9 months of follow-up. Only mild transient local pain and erythema were reported. This case demonstrates that intralesional Candida antigen immunotherapy is a safe, low-cost, and effective option for refractory molluscum contagiosum, providing durable clearance and high patient-reported satisfaction.