. ASSESSMENT OF PRESCRIBING PATTERN AND RESISTANCE STATUS OF ANTIBIOTICS IN CRITICAL CARE UNIT OF TERTIARY CARE HOSPITAL

ABSTRACTBACKGROUND: India is one of the countries with the highest rates of bacterial infections.The crude death rate from infectious diseases in India currently is 417 per 100,000individuals. As a result, AMR is anticipated to have a greater impact in India. AIM: Thecurrent study was conducted to assess the prescribing pattern and resistance status ofantibiotics in Critical Care Unit of tertiary care hospital, who admitted the GGH, Kadapa.METHODS: It was a prospective, observational, cohort-type study conducted in GGH,Kadapa, with a sample size of 104 ICU patients selected viewing the willingness andinclusive criteria. The Institutional Human Ethical Committee of the GGH, Kadapa approvedthe study. Appropriate statistical methods were employed for the data analysis. RESULTS:Among the 102 patients’ males were high in number and the age group of 58-68 was the mostcommonly admitted group in ICU. Sputum was the most commonly analysed specimen andthe isolated organism was Klebsiella pneumonia (16). Based on the susceptibility profileampicillin showed resistance in overall ICU whereas ciprofloxacin showed resistance inantibiotics prescribed with multiple resistance. The clinical outcomes were also assessed atthe time of admission and discharge by comparing their laboratory investigation aresignificance (p-value< 0.05). CONCLUSION: The study concludes that all the antibioticswere prescribed as per the standard treatment guidelines. Among the antibiotics prescribed inthe intensive care unit, ciprofloxacin showed high resistance whereas Piperacillin +Tazobactum (commonly prescribed antibiotic) showed high sensitivity, irrespective of thesystem or organ affected and the isolated microorganism.