The m6A Modification in T Helper Cells Regulates the Pathogenesis of Autoimmune Diseases

Qi Jiang,1,* Xin Wang,2,* Yingping Wu,3 Dawei Cui4 1Department of Blood Transfusion, Shaoxing People’s Hospital, Shaoxing, 312000, People’s Republic of China; 2Department of Rheumatology and Immunology, Shaoxing People’s Hospital, Shaoxing, 312000, People’s Republic of China; 3Department of Laboratory Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, People’s Republic of China; 4Department of Blood Transfusion, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dawei Cui, Depatmernt of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People’s Republic of China, Email [email protected] Yingping Wu, Department of Laboratory Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, People’s Republic of China, Email [email protected]: The pathogenesis of autoimmune diseases remains unclear, which is associated with T helper (Th) cell subsets such as Th1, Th2, Treg and Tfh cells. Recent studies have indicated the involvement of N6-methyladenosine (m6A) modification in the pathogenesis of autoimmune diseases, and m6A also affects the differentiation, and function of Th cells. However, few reports focused on the relationship between m6A modification in Th cell subsets and autoimmune diseases. This review summarizes the latest research progress on m6A modification in common autoimmune diseases, specifically highlighting how various m6A-modifying enzymes influence the differentiation and function of Th cells and disease progression. Elucidating the relationship between m6A modification and Th cells in autoimmune diseases may provide a new perspective for disease prevention and targeted therapy. Finally, this review also elaborates on the impact of m6A on the clinical diagnosis and treatment of autoimmune diseases, as well as the challenges that need to be addressed.Keywords: m6A, T helper cells, treatment, autoimmune diseases