Review Article on Health Related Quality of Life

This review article highlights Health-Related Quality of Life (HRQoL) as an essential multidimensional metric in healthcare, capturing physical, psychological, and social well-being. It explores the dynamic and individualized facets of HRQoL in chronic disease contexts, emphasizing notable gender disparities. The paper reviews economic evaluation approaches such as QALY estimation and assesses the selection, development, and psychometric validation of HRQoL instruments. Challenges—including proxy response use, scoring interpretation, and instrument adaptation—are discussed, alongside the necessity for robust methods to ensure valid, patient-centered outcomes in both clinical practice and research. The article underscores HRQoL’s rising value in health policy, intervention evaluation, and decision-making, reinforcing its critical role in optimizing patient care and guiding resource allocation.