Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study.

Background Self-harm is a major public health concern globally and in South Africa. Individuals with a history of self-harm are at increased risk of unnatural death, including suicide and fatal accidents. This study investigates the incidence and predictors of self-harm and its role as a predictor for subsequent unnatural death. Methods And Findings We conducted a cohort study using insurance claims and vital registration data from beneficiaries of South African medical insurance schemes (2011-2022), aged 10 years or older. We estimated the cause-specific cumulative incidences of healthcare encounters for intentional self-harm (International Classification of Diseases 10th Revision [ICD-10] codes X60-X84) and unnatural deaths (ICD-10 codes V01-Y98), using the Aalen-Johansen method. We assessed predictors of both outcomes using Cox regression. We followed 1,356,119 beneficiaries (median age 33 years, 52.2% female) for a median of 3 years, during which 7,510 (0.6%) had a healthcare encounter for self-harm. The 5-year cumulative incidence of self-harm ranged from 0.2% in males aged 10-14 to 2.1% in females aged 15-24. Sex, age, and mental disorders were strong predictors for self-harm, while HIV was a modest predictor. Among individuals who survived a self-harm event, the five-year cumulative incidence of unnatural death was 3.43% (95% CI [2.38, 4.76]) for males and 0.77% (95% CI [0.48, 1.19]) for females. Non-fatal self-harm was a strong predictor of subsequent unnatural death in both males (hazard ratio [HR] 7.03, 95% CI [5.27, 9.39]) and females (HR 4.63, 95% CI [3.00, 7.15]). The study's main limitations include potential under-ascertainment of self-harm incidence due to reliance on routine data, and the unavailability of the exact cause of death, preventing analysis of suicide. Conclusion Self-harm is common among beneficiaries of South African private medical insurance, with the highest risk in young females and individuals with mental disorders. These groups may benefit from targeted screening and early intervention. Non-fatal self-harm was a strong predictor of subsequent unnatural death, underscoring the need for suicide-specific brief interventions for individuals presenting with self-harm.