<b><i>MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review</i></b>

This review provides an in-depth analysis of how <b>microRNAs (miRNAs)</b> contribute to the onset, progression, and therapeutic modulation of <b>neurodegenerative diseases (NDDs)</b> such as <b>Alzheimer’s disease (AD)</b>, <b>Parkinson’s disease (PD)</b>, <b>amyotrophic lateral sclerosis (ALS)</b>, and <b>Huntington’s disease (HD)</b>.It highlights the emerging importance of <b>miRNA signatures</b> as <b>molecular biomarkers</b> for early detection and personalized interventions, focusing on both <b>molecular mechanisms</b> and <b>clinical applications</b>.Key themes include:Mechanistic insights into <b>miRNA dysregulation</b> in neuronal pathways, synaptic signaling, and neuroinflammatory cascades.Overview of <b>modern miRNA detection platforms</b>, including digital PCR, nanoparticle-based assays, and biosensor technologies.Evaluation of <b>miRNA-based therapeutics</b>, encompassing antisense inhibitors, mimics, and RNA delivery systems tailored to overcome the <b>blood–brain barrier (BBB)</b>.Discussion on <b>standardization challenges</b>, <b>computational modeling</b>, and <b>translational strategies</b> needed to move miRNA research from laboratory discovery to clinical reality.By integrating findings from molecular neuroscience, bioinformatics, and nanobiotechnology, this article underscores how <b>miRNA-centered approaches</b> are shaping the future of <b>neurodiagnostics</b> and <b>RNA therapeutics</b>.📖 <b>Read the Full Reviews:</b><b>Azam, H.M.H. et al.</b> <i>MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies—advances and challenges.</i> <i>Neurological Sciences</i> (2025). https://doi.org/10.1007/s10072-025-08419-w<b>Azam, H.M.H. et al.</b> <i>MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review.</i> <i>Frontiers in Molecular Neuroscience</i> (2024). https://doi.org/10.3389/fnmol.2024.1386735#miRNA #Neurodegeneration #Neuroscience #Neurobiology #RNAResearch #Alzheimers #Parkinsons #ALS #Huntingtons #Biotechnology #PrecisionMedicine #MolecularDiagnostics #Biosensors #Bioinformatics #NeuroDiagnostics #TranslationalMedicine #FrontiersJournals #SpringerNature #ResearchImpact #ScienceCommunicatio