A STUDY OF CO-MICRONIZATION IN FORMULATION OF RAPID DISPERSIBLE TABLETS

The concept of rapid dispersible, fast dissolving, quick dissolving, and Orodispersible tablets dosage forms have acquired great importance in recent years due to their unique properties and advantages over other available dosage forms. The micronization of TA and diluents was done by using Air-jet mill. The comicronization of formulation was done as per the given details in table. Total three cycle of micronization was completed to insure the proper particle size reduction of blend. There is no micronization of formulation F-1 was done; it was basically used as reference to check the impact of micronization and co-micronization. But sifting of Tolfenamic acid (non-micronized) of Formulation F-1 was done through #60 meshes to insure the uniformity of Tolfenamic acid in blend. Keywords: Rapid dispersible tablets, fast dissolving tablets, quick dissolving tablets, Orodispersible tablets, micronization, TA, diluents, Air-jet mill, co-micronization, particle size reduction.