The By-product Metabolic Effect of Saccharomyces Ellipsoideus against Some Medically Important Bacterial Species from Conventional and Modified Growth Media

Saccharomyces ellipsoideus is a yeast species with metabolites that enhance resistance to acidity, act as an anti-inflammatory agent, and stimulate the immune system. Additionally, S. ellipsoideus exhibits antimicrobial effects against intestinal bacterial pathogens. S. ellipsoideus yeast was sourced from local markets in Ramadi City to be tested against the growth of bacterial species, including Enterococcus faecalis, Staphylococcus epidermidis, Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa. Bacterial susceptibility to S. ellipsoideus metabolites was tested using the agar diffusion method. The study findings indicate that S. ellipsoideus cultivated in modified media demonstrated increased antimicrobial activity against the five bacterial species over time. The most significant antimicrobial effects were observed against E. coli, P. aeruginosa, and S. marcescens, particularly after an incubation period of 168 hours, where inhibition zones of 19 mm and 18 mm were recorded, respectively. S. ellipsoideus effectively inhibits the growth of five bacterial species. Moreover, the antimicrobial activity of S. ellipsoideus was significantly enhanced when grown in modified media compared to nutrient media.