Potentials of a Drug Based on Regulatory Polypeptides in the Treatment of Patients with Intermittent Claudication

INTRODUCTION: Despite the achievements of modern vascular surgery, one of the most significant problems of conservative treatment of atherosclerosis of the lower limb arteries is a steady progression of the atherosclerotic process. The key pathogenetic factor of atherosclerosis is endothelial dysfunction. Currently there are known several methods for correcting endothelial dysfunction, both drug and non-dug ones. AIM: To analyze various sources of domestic and international literature examining the main treatment methods for atherosclerosis of the lower limb arteries by correcting endothelial dysfunction. This article presents a literature review of PubMed, Medline, eLibrary databases, as well as relevant Russian scientific articles found using Google. The obtained information was combined, structured and analyzed to study the optimal methods for correcting endothelial dysfunction, including the effect of the drug based on regulatory vascular peptides on the pathogenesis of atherosclerosis. CONCLUSION: To date, possible methods of drug correction of endothelial dysfunction have been identified, among which it is important to note the effectiveness of the use of polypeptides isolated from cattle vessels, which positively affect the main links in the pathogenesis of atherosclerosis, normalizing endothelial function and thereby increasing the pain-free walking distance in patients with obliterating atherosclerosis of the arteries of the lower extremities. However, all of the above methods of correcting endothelial dysfunction require further comprehensive study and evaluation.