Study the relationship of osteopontin with blood pressure in type II diabetics without and with renal failure

Elevated serum levels of Osteopontin(OPN) have been associated with Diabetic Nephropathy.Aim of the study was to investigate the relationship between OPN serum levels and blood pressure in Type 2 diabetes mellitus(T2DM) with and without Renal Failure.Methods:In this study, we measured serum levels of (OPN), Electrolytes(Na+ , k+), serum Phosphorous level(PO4) and Blood Pressure in 50 Patients among them, 25 diabetic patients without Renal Failure and 25 with Renal Failure and 30 control subjects .Results:This study found that serum OPN levels(ng/mL) were higher in T2DM without and with Renal Failure than in control group(6.219+0.732 vs4.611+1.296)(7.497+1.758 vs4.611+1.296)sequentially. The levels of DBP(mmHg) non-significant difference between T2DM without Renal Failure than in control group (82.8+15.14 vs86+10.03) and it was Lower in T2DM with Renal Failure than in control group(68.28+14.34 vs86+10.03).The SBP(mmHg) in three groups showed no significant difference (129.3+12.58vs128.4+19.72vs136.9+15.24).As for MAP non-significant difference between T2DM without Renal Failure than in control group(98+15.84vs100.4+9.65) and it was Lower in T2DM with Renal Failure than in control group(91.16+12.98 vs100.4+9.65 ).Conclusions:Serum OPN levels significantly increased in T2DM without and with Renal Failure patients comparison to healthy subjects .The blood pressure is represented by the DBP and MAP were significantly in T2DM without Renal Failure patients than in controls.