Vitamin D supplementation influences the serum lipid profile in the Jordanian population with vitamin D deficiency

Purpose: To evaluate the association between vitamin D supplementation and changes in lipid profile in a Jordanian population with vitamin D deficiency. Methodology: A total of 95 participants, comprising 35 females aged 15-73 years, were recruited for this prospective investigation and administered vitamin D supplements. Blood specimens were examined for lipid profile characteristics and 25(OH)D3 amounts. Vitamin D supplementation protocole involved the weekly dosing of a single tablet containing 50,000 IU of cholecalciferol for the first four weeks, and bi-weekly medication for the final four weeks. Findings: Before intervention, vitamin D, calcium, total cholesterol, high-density lipoprotein (HDL), decreased lowdensity lipoprotein (LDL), and triglyceride (TG), had no statistical difference between males and females (p=0.231, 0.111, 0.331, 0.821, 0.271, and 0.371, respectively). A noteworthy decrease in serum total cholesterol levels (194±22 mg/dL to 187±19 mg/dL, p<0.05) was noted after vitamin D administration. Although there was a non-significant trend towards LDL cholesterol levels (107±18 mg/dL to 98±15 mg/dL), as well as TG levels (135±26 mg/dL to 128±17 mg/dL), these changes were not statistically significant. Conversely, there was a minor and insignificant rise in the levels of HDL cholesterol (55±13 mg/dL to 57±12 mg/dL). Post intervention, lipid profile parameters correlated positively with vitamin D (r=0.77 for total cholesterol, 0.84 for TG, 0.80 for HDL, and 0.29 for and LDL) with a significant difference (p<0.001, <0.001, <0.001, and 0.004, respectively). Conclusion: Vitamin D may influence certain aspects of lipid metabolism, but broader conclusions regarding overall lipid profile improvement should be made cautiously.