Leukemoid Reaction and Sudden Hearing Loss in Early Cervical Cancer: A Case Report and Review of the Literature

Shuai Feng,1,2 Yueju Yin,1 Hui Guo,1 Dapeng Li1 1Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of China; 2The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of ChinaCorrespondence: Dapeng Li, Email [email protected]: The manifestation of a leukemoid reaction in the cervical cancer is an uncommon occurrence. Three cases of advanced, recurrent or metastatic cervical cancer with leukoid reaction have been reported in the past, but no early cervical cancer with leukoid reaction has been reported. Paraneoplastic neurological syndromes (PNS) are rare and have not been reported in cervical cancer.Case Presentation: A 38-year-old woman presented was admitted to hospital because of sudden hearing loss in her right ear, and routine blood tests showed abnormally elevated white blood cells and neutrophils (WBC: 43.87*109/L, NEU: 39.63× 10^9/L). Cervical biopsy and pathological examination revealed cervical squamous cell carcinoma. Infection and hematological diseases such as leukemia and bone marrow metastasis were ruled out. After operation WBC and NEU counts decreased and remained at normal levels and the hearing condition of her right ear was significantly improved than before. No leukopenic drugs or neurotrophic agents that improve hearing were used during the treatment period.Conclusion: This is the first case of cervical cancer presenting with sudden deafness and the first case report of early cervical cancer complicated by a leukemoid reaction, which may be related to a paraneoplastic neurological syndrome.Keywords: leukemoid reaction, paraneoplastic neurologic syndrome, cervical cancer