Substrate Divergent 4π/6π Electrocyclization of CF<sub>3</sub>‐Quinolone Heterodendralenes
Herein, a substrate‐divergent 4π/6π electrocyclization of hitherto unknown CF 3 ‐heterodendralenes is disclosed, generated in situ from the 4‐methyl‐3‐trifluoroacetyl quinolones. The reaction favors 4π‐electrocyclization in the presence of a phenyl substituent, producing cyclobuta[ c ]quinolones featuring a challenging CF 3 ‐all‐carbon quaternary stereocenter. Conversely, vinyl substitution promotes 6π‐electrocyclization to provide CF 3 ‐dihydro‐phenanthridones.
Institutions
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1002/ejoc.202500500
- Citations
- 1
- Primary Topic
- Computer Science and Engineering
- Type
- article
- Field-Weighted Citation Impact
- 2.48
Funders
- Council of Scientific and Industrial Research, India