Translational Concept: Intergenerational School Gym Dream (MSSM) — Repairing Public Health via Skeletal-Muscle Strength (v1.1, EN)

TL;DR. Intergenerational School Gym Dream (MSSM) is a translational, school- and community-anchored program that treats skeletal-muscle strength as first-line public-health infrastructure. We connect the Perfusion–Hypoxia Hypothesis (PHH v3.1.6; DOI: 10.5281/zenodo.17253377) with a standardized resistance-training curriculum deliverable in ordinary schools, across generations, with pre-specified clinical and functional endpoints and a 24-month roadmap for replication at scale. Why it matters. Cohort-wide strength decline correlates with metabolic risk, vascular dysfunction, and poorer learning/functional outcomes. MSSM operationalizes strength as a measurable, equitable intervention that fits timetables, budgets, and staffing in real schools. Intervention. A progressive, evidence-informed resistance-training curriculum (children, teens, parents, teachers, seniors) integrating warm-ups, main sets, and cool-downs, plus low-equipment fallbacks for constrained settings. Delivery models: (1) Strength & Health Lesson integrated into school hours; (2) after-school/community blocks; (3) intergenerational weekend sessions. Primary endpoints (12–24 months). Vascular function: Flow-Mediated Dilation (FMD) and Pulse Wave Velocity (PWV) — co-primary. Microvascular glycocalyx: Perfused Boundary Region (PBR) — co-primary/exploratory. Functional brain & cardiac perfusion (sub-studies): Arterial Spin Labeling MRI (ASL, CBF/ATT) and quantitative perfusion cardiac MRI (qPerf-CMR, MBF/MPR). Functional & educational outcomes: strength tests (1RM proxies/isometrics), motor skills, attendance, fatigue, and classroom on-task time. Design & QA. Pragmatic, stepped roll-out with school-level clustering. A pre-registered analysis plan; Logic Model, SOP/QA/QC, and a one-page Translation Matrix specify components, fidelity checks, and adaptation rules. Pre-specified “killer experiments” isolate the shear-stress contribution of resistance training versus non-shear controls. Package contents (in this record). Concept/logic-model figures and a 24-month roadmap; Translational Concept (PDF/DOCX); SOP/QA/QC; Translation Matrix; Landscape & Novelty note; and a Zenodo-ready ZIP for reuse. All materials are CC BY 4.0 with clear versioning and a changelog. Equity & implementation. Low-cost entry (bodyweight/bands) with scalable hardware options; accessibility adaptations (tempo, cues, adjustable seating/handle heights); and intergenerational participation to amplify adherence and social support. Open science. This record is linked to PHH v3.1.6 via isSupplementTo and will cross-reference emerging datasets, protocols, and pre-registrations. Users are invited to fork materials, report outcomes, and contribute improvements via subsequent Zenodo versions. Intended users. School leaders, PE/health educators, municipal health officers, clinicians, NGOs, and researchers in implementation science, vascular biology, and education. How to cite. Cite this record’s DOI for the translational package, and PHH v3.1.6 (DOI: 10.5281/zenodo.17253377) for the underlying mechanistic model. Disclaimer. Research & education use only; not medical advice.