Clinical significance of coagulation function status and platelet detection in patients with acute cerebral infarction

Objective: To measure and analyze platelet and coagulation function-related indicators in patients with acute cerebral infarction (ACI) and explore their clinical significance. Methods: The multivariate analysis of age, smoking, gender and drinking was carried out in the study, and KMO: 0.651（p＝0.000, indicating that the analysis could be carried out. A total of 80 cerebral infarction patients admitted to Chongzhou People’s Hospital from January 2023 to May 2025 were enrolled and divided into an ACI group (40 cases) and a non-ACI group (40 cases) based on disease severity. Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer (D-D), and platelet count (PLT) were measured and compared between the two groups. Logistic Regression analysis was used to assess the relationships among PLT, PT, APTT, FIB, TT, and D-D in the ACI group. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of FIB, D-D, and PLT in ACI. Results: Compared with the non-ACI group, the ACI group showed significantly higher levels of D-D and PLT, but the differences were not statistically significant (P > 0.05). Spearman correlation analysis revealed a negative correlation between D-D and other parameters in ACI patients (P < 0.05). ROC curve analysis indicated that the area under the curve (AUC) for D-D was 0.971, demonstrating statistical significance (P < 0.05). Conclusion: The detection of platelet and coagulation function-related indicators in ACI patients holds significant clinical value for diagnosis, early prediction of thrombosis, and assessment of disease severity.