Rabies Revisited: From Pathogenesis to One Health Solutions for Elimination

Rabies is a zoonotic disease, transmitted to humans mostly through transmission of Lyssavirus by bites of infected dogs. The 2025 World Rabies Day theme, "Act Now: You, Me, Community," underscores the collective responsibility in combating rabies. This theme emphasizes the importance of individual actions, community engagement, and collaborative efforts across sectors to eliminate rabies. By vaccinating dogs, educating the public, and ensuring access to post-exposure prophylaxis, we can significantly reduce and eventually eliminate rabies as a public health threat. This manuscript delves into the pathogenesis of rabies, its clinical manifestations, diagnostic methods, and, most importantly, the strategies for its prevention and control, aligning with the global call to action for a rabies-free world.