Sonochemical‐Promoted One‐Pot Multicomponent Synthesis of 2,4‐Disubstituted‐1,3‐Thiazolidin‐4‐One and Toxicity Evaluation as Potential Insecticidal Agents

ABSTRACT In the current study, we present an efficient and simple method for the synthesis of 1,3‐thiazolidin‐4‐one compounds 4–11 using a one‐pot three‐component reaction. This process involves the reaction of 3‐pyridyl isothiocyanate ( 1 ), primary aliphatic or aromatic amines 2a–h , and dimethyl acetylenedicarboxylate (DMAD) in ethanol under ultrasonic conditions. The ultrasonic method for designing 1,3‐thiazolidin‐4‐one compounds is a simple and efficient methodology that produces high‐purity products with little effort. It has substantial advantages over traditional methods in terms of cost and energy consumption, making it an efficient and sustainable choice for chemical reactions. One of the main forces behind the creation of new insecticidal substances is the growing resistance to traditional chemical pesticides. In order to overcome this difficulty, scientists are investigating novel pesticide classes with distinct modes of action, so that the novel target synthesized compounds can be screened for insecticidal activities against nymphs and adults of Aphis craccivora .