The Potential of Creatinine-Fibrinogen Ratio Levels as an Indicator of Severe Placenta Abruptio: A Retrospective Case Control Study

Fikriye Işıl Adıgüzel,1 Yunus Öztoprak,1 Ahmet Zeki Nessar,2 Gülsüm Uysal,1 Sadık Kükrer,1 Cevdet Adıgüzel,1 Raziye Narin1 1University of Health Sciences Adana City Hospital, Department of Obstetrics and Gynecology, Adana, Turkey; 2Osmaniye State Hospital, Department of Perinatology, Osmaniye, TurkeyCorrespondence: Fikriye Işıl Adıgüzel, Adana City Training and Research Hospital, Department of Obstetrics and Gynecology, Adana, Turkey, Tel +905063158572, Email [email protected]: To compare the relationship between the severity of placenta abruptio and creatinine-fibrinogen ratio (CFR).Patients and Methods: Patients with mild and severe placental abruption were separated. Patients with ≥ 1 maternal complications (eg, DIC, hypovolemic shock, blood transfusion, hysterectomy, acute kidney injury, death) were classified as severe placental abruption, while those without were classified as mild. The two groups were compared in terms of hematological parameters and CFR levels at the time of hospital admission.Results: In the study of patients classified by the severity of placental abruption, there were 107 individuals in the mild group and 51 in the severe group. The severe group had elevated creatinine and diminished fibrinogen levels (p = 0.001 and p < 0.001, respectively). The CFR levels of the severe group was significantly higher (p < 0.001). CFR levels were used for ROC analysis to differentiate mild and severe abruptio placenta. CFR had an AUC value of 0.730 (p < 0.001). CFR cut-off values were 0.1381 with 64.7% sensitivity and 76.6% specificity. In this analysis, logistic regression revealed significantly greater CFR (OR 1.064, 95% CI: 1.010– 1.220; p = 0.019).Conclusion: CFR appears to be an effective indicator for predicting severity of placenta abruptio in pregnant women with placental abruption. Keywords: creatinine-fibrinogen ratio, placental abruption, severity of placental abruption