Secondary Perianal Paget’s Disease Originating From Adenocarcinoma of the Anorectal Junction: A Case Report

Jun He,1,* Rong-Chao He,2,* Jian-Zhong Peng,3 Hou-Dong Wang,1 Tao Wang,3 Si-Jia Lu,4 Xiu-Feng Zhang,1 Zhong Shen1 1Department of Colorectal Surgery, Hangzhou Third People’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Dermatologic Surgery, Hangzhou Third People’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 4Department of Pathology, Hangzhou Third People’s Hospital, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhong Shen, Email [email protected] Xiu-Feng Zhang, Email [email protected]: Secondary extramammary Paget’s disease (EMPD), originating from the cutaneous dissemination of malignant cells, represents a rare subtype prone to misdiagnosis. This study presents a case of secondary perianal Paget’s disease (PPD) associated with adenocarcinoma at the anorectal junction. Preoperative full-thickness mapping biopsy was utilized for the assessment of lesion margins. The patient demonstrated favorable postoperative recovery following a multimodal therapeutic regimen.Keywords: Extramammary Paget’s disease, perianal Paget’s disease, anorectal cancer