Cardio-toxicity of zinc oxide nanoparticles and Senecio glaucus L. with the prospective therapeutic impact of gallic acid in albino rats

Zinc oxide nanoparticles (ZnO NPs) are the utmost innovative nanoparticles used in the imperative claims. Senecio glaucus L. plant (SP) is an ordinary plant found in warm places. Gallic acid (GA) displays as a dynamic antioxidant against the innumerable pollutants. The existing study was intended to appraise the lethal influences of either alone or combined treatments of ZnO NPs and SP in the cardiac tissue and to dissect the cytoprotective effect of GA via biochemical and histopathological evaluations for 30 days in the albino rats. Rats were allocated into 8 groups with orally inoculated: Control, GA (100 mg/kg), ZnO NPs (150 mg/kg), SP (400 mg/kg), GA+ZnO NPs (100,150 mg/kg), GA+SP (100,400 mg/kg), ZnONPs+SP (150,400 mg/kg), and GA+ZnO NPs+SP (100,150,400 mg/kg). Our study signposted that ZnO NPs and SP significantly changed in the activity of creatine kinase enzyme (CK-MB) and the level of total lipids (TL) compared to the control group, (p<0.001). They incited several histological variations in heart tissue, such as inflammation, edema, and fibrotic zones. The toxic influence of combined treatment was more than the influence of the single treatment. Contrariwise, GA alleviated some of these deleterious effects and adjusted the integrity of the cardiovascular fibers. This study indorsed that ZnO NPs and SP is cardiotoxic agents; however, GA has a favorable cardioprotective agent against a cardio-toxicity prompted by ZnO NPs and SP.