Exercise decreases the number and modifies the transcriptome of M1 macrophages and CD8+ T cells in occluded epicardial adipose tissue of female pigs

Exercise mitigates epicardial adipose tissue (EAT) inflammation via modulation of immune cell subpopulations, decreased TNF superfamily, and increased <i>PPARG</i> gene expression, and decreased communication between adipocytes and immune cells. However, the effect of exercise on the EAT immune environment is modulated by coronary artery occlusion status. Future studies of the impact of exercise and coronary artery occlusion on EAT would benefit from using a progressive nutritionally induced model of coronary artery disease.