"ADVANCEMENTS IN ANALYTICAL METHODOLOGIES FOR THE DETERMINATION OF BUMETANIDE IN COMBINED DOSAGE FORMS"

Bumetanide, a potent loop diuretic, is used in managing edema in congestive heart failure, renal impairment, and hepatic cirhosis. It has also been linked to neurological disorders, increasing the need for reliable analytical methods. Accurate determination of Bumetanide in combined dosage forms is crucial for quality, safety, and efficacy. Challenges include matrix complexity, interference from co-formulated drugs, and stability issues. Advancements in analytical methodologies have improved resolution, accuracy, and faster analysis. Hyphenated techniques like LC-MS/MS have enhanced sensitivity and specificity. Green analytical approaches and Quality by Design principles promote eco-friendly practices. Future perspectives emphasize the need for innovative, automated, and environmentally conscious methodologies for bumetanide determination in combined dosage forms.