Management of upper gastrointestinal bleeding due to peptic ulcers in cardiac patients: A retrospective study

Background: Cardiac patients are at increased risk of upper gastrointestinal bleeding (UGIB) due to frequent use of antithrombotic agents. This study examines the characteristics of peptic ulcer bleeding (PUD) in this population. Methods: A 4-year retrospective study (2020–2024) was conducted at Ibn Sina University Hospital, Rabat. Cardiac patients presenting with UGIB and confirmed PUD on endoscopy were included. Results: Among 418 UGIB cases, 73 had cardiac disease; 31 had PUD. Most were male (58%) with a mean age of 68.4 years. Antithrombotics were used by 83.9%. Endoscopic hemostasis was needed in 35.5%; rebleeding occurred in 12.9%. Common risk factors included age, prior PUD, NSAID use, and dual therapy. Conclusion: UGIB in cardiac patients poses management challenges due to bleeding and thrombotic risks. Prevention with PPIs and tailored antithrombotic strategies is essential.