Formulation characterization and evaluation of In-Situ nasal gels of amitriptyline

The main aim of the present work is to formulate and evaluate Amitriptyline In-Situ Nasal gels. To achieve more constant blood levels with lower dosage of drugs by continuous drug input and by passing hepatic first pass metabolism and consequent degradation. In FTIR & DSC spectra there is no incompatibility between pure drug, polymers & lipids. The Formulation of Amitriptyline hydrochloride In-Situ Nasal gels, The evaluation of Amitriptyline hydrochloride In-Situ Nasal gels. Carbopol containing gels were found to be sparkling and transparent Poloxamer, Hydroxy Propyl Methyl cellulose gels were found to be translucent and white viscous. The PH value of all developed formulations of gels (F1-F8) was in the range of 6.8 to 6.9. Spread ability of gels was in the range 23.99 - 26.37 g.cm/sec. Viscosity of various formulated gels was found in range of 942 to 938 centipoises. The percentage drug content of all prepared gel formulations were found to be in the range of 98.93 to 84.47 %. The percentage drug content of formulations was found satisfactory. The gel strength of all prepared formulations of gels was found to be in the range of 64 to 95%. The In-vitro release of Amitriptyline hydrochloride was prolonged release of drug ranges from 95 % of released within 7 hours. Among the eight formulations the best formulation is F1 formulation follows both Zero order and Korsemeyer-Peppas models, It indicates diffusion release mechanism followed by non-fickian transport.