Antidiabetic Activity of Artocarpus Heterophyllus Leaf Extract: In vitro Assessment and Mechanistic Insights

The rising global prevalence of diabetes has prompted the search for alternative therapeutic strategies, particularly those based on natural sources. This study evaluates the in vitro antidiabetic potential of Artocarpus heterophyllus leaf extract, focusing on its effects on key enzymes involved in carbohydrate digestion and its antioxidant properties. The extract was tested for its ability to inhibit alpha-amylase and alpha-glucosidase, two enzymes crucial for glucose absorption. Additionally, the antioxidant activity of the extract was assessed, as oxidative stress plays a significant role in the pathogenesis of diabetes. The results revealed that Artocarpus heterophyllus leaf extract effectively inhibited both alpha-amylase and alpha-glucosidase, suggesting its potential to control postprandial blood sugar levels. Furthermore, the extract demonstrated significant antioxidant activity, which may help mitigate oxidative damage commonly associated with diabetes. These findings provide mechanistic insights into the antidiabetic effects of Artocarpus heterophyllus leaf extract and support its potential as a therapeutic agent for diabetes management.