<b>Periprostatic Adipose Tissue Microenvironment: Metabolic and Hormonal Pathways During Prostate Cancer Progression</b>

The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and ispart of the microenvironment. It was shown that PPAT secretes factors and fatty acids(FAs) that alter the microenvironment of the PCa. The PPAT secretome of patients withPCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related toenergy production, indicating a greater energy requirement by the tumor, when comparedto that of patients in the PCa-T2 stage (PPAT-T2). PPAT-T3 also shows enrichment inpathways related to hormone response, polyamine synthesis, and control of proteinsynthesis, through amino acid, RNA, and nucleotide metabolism. PPAT-T2 and PPATBPHsecretomes have less complex metabolic profile, both related with energy balance,while PPAT-BPH has hormone response through insulin pathway. Undoubtedly, a deepercharacterization of the human PPAT will lead to a better understanding of the disease andpossibly allow new stratification factors and the design of a specific therapy that targetscrucial components of the tumor microenvironment as another way to treat or controlthe disease.