Incidence and influencing factors of venous thromboembolism after laparoscopic radical resection for colorectal cancer

[Objectives] To analyze the incidence and influencing factors of venous thromboembolism (VTE) in patients undergoing laparoscopic radical resection for colorectal cancer (CRC). [Methods] A total of 140 CRC patients who underwent laparoscopic radical resection at Changshu No.2 People’s Hospital from June 2021 to June 2024 were enrolled. VTE occurrence within 2 weeks postoperatively was recorded. Patients were divided into VTE and non-VTE groups based on VTE status. Caprini score (assessed within 24 hours postoperatively) and clinical parameters were compared between groups. [Results] Among 140 patients, 26 (18.6%) developed VTE, including 25 cases of the deep vein thrombosis of lower extremities and 1 case of pulmonary embolism. The median Caprini score in the VTE group (n=26) was 4 (IQR,3-4), significantly higher than that in the non-VTE group [n=114; median: 2 (IQR, 2-2)] (P<0.05). Compared to the non-VTE group, the VTE group had older age, higher body mass index (BMI), higher preoperative D-dimer level, higher preoperative plasma viscosity level, longer operative time, and longer postoperative immobilization time (P<0.05). No significant differences were observed in sex ratio, Tumor-Node-Metastasis stage, preoperative radiotherapy, preoperative chemotherapy, preoperative platelet count, preoperative fibrinogen level, preoperative prothrombin time, blood transfusion history, prior VTE history, atherosclerotic disease history, postoperative anastomotic leakage, or postoperative bowel obstruction (P>0.05). [Conclusion] VTE incidence is notable after laparoscopic radical resection for CRC. Patients with VTE exhibit older age, higher BMI, higher preoperative D-dimer level, higher preoperative plasma viscosity level, longer operative time, and longer postoperative immobilization time compared to non-VTE patients.