Clinical Efficacy of Plant-derived Nano-Exosomes for Skin Regeneration

Purpose: Extracellular vesicles (exosomes), which are nanosized lipid bilayerenclosed vesicles containing a diverse cargo of proteins, lipids, and nucleic acids, serve as a fundamental mechanism for intercellular communication. Their role as natural delivery systems makes them highly promising for biomedical applications. Here, we assessed the cosmetic efficacy of the novel topical formulation “CELLMULA EXO Solution” containing four types of plant-derived nano-exosomes.Methods: A cohort of 22 adult female volunteers applied the test formulation twice daily for two weeks. Skin parameters were quantitatively measured at baseline and endpoint to assess changes in elasticity, moisture, pigmentation, and texture.Results: CELLMULA EXO Solution elicited robust and statistically significant improvements across all key skin metrics within the two-week study period. Skin elasticity and moisture content increased significantly, while hyperpigmentation and pore-area roughness were considerably reduced. Remarkably, skin hydration levels increased by over 100% from baseline, a rapid and substantial physiological change.Conclusion: This study provides the first clinical evidence that a synergistic combination of plant-derived exosomes can effectively rejuvenate aged skin. The formulation significantly improved skin appearance by enhancing elasticity, hydration, pigmentation, and texture, suggesting its potential as a potent anti-aging ingredient.