A study evaluating the effect of vitamin D and PUFA supplementation coupled with acupuncture therapy on the prognosis of post-stroke fatigue: A comparative study

he present study was done to evaluate the impact of vitamin D, PUFA supplementation and acupuncture therapy on the prognosis of PSF in stroke patients hospitalized to the Institute of Medical Sciences & SUM Hospital (IMS and SH),Medical College and Hospital of Siksha 'O' Anusandhan, Bhubaneswar, between August2016and May2018.After the final follow-up of the group that received PUFA, Vitamin Supplements, and acupuncture therapy The patients had HDL cholesterol1.69 ± 2.0 mmol/Lat pre-treatment, which was 3.62 ± 1.6 mmol/L, total cholesterol level 5.9 ± 2.2mmol/Lat pre-treatment, which was 5.02± 1.2 mmol/L, LDL cholesterol level 3.9 ± 2.0 mmol/Lat pre-treatment, which was 3.0 ± 0.6 mmol/L, normal fasting blood glucose concentration 6.9 ± 1.5mmol/Lat pre-treatment, which was 5.9± 1.0 mmol/L, FSS 6.8(4.6-9) at pre-treatment, which was 2.0and 25-(OH)-Dlevel 14.6± 3.0 ng/mlat pre-treatment, which was 29.9± 4.0 ng/ml. Vitamin D, PUFA supplementation could improve fatigue symptomsand outcomes in PSF patients. We suggest that acupuncture might be an effective and safe adjuvant therapy for PSF. The methodological quality of the evidence in this study is inadequate, and it is further limited by the number of trials included and the small sample size, which may result in inaccurate research findings. Therefore, high-quality research are still needed to confirm the benefits of Vitamin D, PUFA and acupuncture for PSF.