GC-MS Characterized Novel Polyherbal Gel for the Treatment of Impetigo: A Study on Its Antimicrobial and Dermatological Benefits

Impetigo is a common skin infection in children which is mainly caused by Staphylococcus sp or Streptococcus pyogenes. The main symptoms of the infection include the formation of honey colored scab over the sores. Managing impetigo can also be difficult due to increasing antibiotic resistance and the need for strict hygiene to prevent reinfection or transmission. In the present study, organism responsible for the Impetigo was isolated, identified and polyherbal extract prepared using the medicinal plants Azadirachta indica, Calotropis gigantea, Wrightia tinctoria and Acalypha indica was prepared. Antimicrobial activities of Individual plant leaves extract and polyherbal preparation was evaluated. A polyherbal gel was prepared as a topical application and its antimicrobial activity was analyzed. Organism causing Impetigo was identified as Staphylococcus aureus. The maximum antimicrobial activity was exhibited by 100 µl of Wrightia tinctoria leaf extract. The polyherbal extract and gel showed the maximum zone of inhibition as 15mm and 13 mm respectively in 100 µl volume samples. Polyherbal gel was analyzed by GC-MS which showed the presence of the compounds having the ant inflammatory, antibacterial and skin smoothening. The prepared polyherbal gel can be used as topical application for the treatment of Impetigo and restoration of skin texture.