Neurological Manifestations of Wegener's Granulomatosis - Case Report

BACKGROUND: Granulomatosis with polyangiitis is an inflammatory process that affects the endothelium of small and medium blood vessels. It is an autoimmune disease, which is systemic and attacks multiple organ systems. It is also called Wegener's granulomatosis (Wegener Granulomatosis), according to the German pathologist Wegener who described the first cases of granulomatous inflammation of small and medium blood vessels. CASE PRESENTATION: This paper presents a clinical case report of a middle-aged female patient with Wegener's granulomatosis, treated at the Department of Neurology at City General Hospital 8th September. The patient's initial symptoms began nine years ago. The course of her disease is chronic with a progressive nature, followed by relapses and exacerbations. The patient was promptly diagnosed and treated with appropriate therapy, which she tolerates well. The definitive diagnosis is established by biopsy of the affected tissue and pathohistological analysis, where the presence of granulomas is detected. CONCLUSION: This form of polyangiitis is significant for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in the patient's blood. But their absence does not exclude the disease. In terms of therapy, drugs are used that regulate the patient's immune system. We must be aware of the risk of complications and worsening of the course of the disease. This condition requires a multidisciplinary approach to treatment.