A COMPREHENSIVE REVIEW ON "UNLOCK SUPERIOR EYE HEALTH: WHY INSITU-GELS ARE A GAME CHANGER,

The conventional treatment of ophthalmic diseases primarily focused on the topical application of eye drops. However, these formulations often exhibit low bioavailability and limited therapeutic efficacy due to rapid precorneal elimination mechanisms such as drainage and tear turnover. To address these challenges, in situ gelling systems have been developed. These systems are administered as liquid drops but undergo a sol-to-gel transition upon contact with the ocular surface, typically triggered by physiological factors like pH, temperature, or ionic strength. This transition enhances the residence time of the drug in the precorneal area, thereby improving its bioavailability and therapeutic response. In this context, the present study focuses on the formulation and evaluation of an ophthalmic delivery system for insitu activated gel system. These drug delivery systems are based on the principle of pH-triggered in situ gelation, using polymers such as polyacrylic acid (Carbapol 940) as gelling agent and HPMC K4M and HPMC K15M) as viscosity enhancers. This approach aims to provide a sustained release of the drug, thereby prolonging its therapeutic effect and enhancing patient compliance.