Study of the Effects of Sorghum bicolor (Poaceae) on Duodenal Motility in Rabbits

In this study,carried out to evaluate the gastrointestinal tolerance of the aqueous extract of Sorghum bicolor leaf sheath used in the treatment of anemia in Côte d'Ivoire. An aqueous extract of whole Sorghum bicolor seeds was prepared using cold maceration method. Segments of rabbit duodenum were used for the experiment. Aqueous extracts of Sorghum bicolor induce a dose-dependent reduction in duodenal muscle contractions. Aqueous extracts of Sorghum bicolor inhibit acetylcholine-induced tonic concentrations by 94% at a concentration of 1000 µg/mL. The aqueous extract of Sorghum. bicolor had intestinal muscle relaxant properties. These results support its pharmacological potential as an antispasmodic agent.