ERYTHEMA NODOSUM REVEALING SILENT CELIAC DISEASE IN CHILDHOOD: A CASE REPORT

Background: Erythema nodosum is the most frequent form of panniculitis, Its association with celiac disease remains uncommon, particularly in children. Case presentation: We report the case of a child presenting with recurrent erythema nodosum without gastrointestinal symptoms. Laboratory findings revealed severe iron deficiency despite prolonged oral supplementation. Serologic testing demonstrated elevated anti-transglutaminase IgA antibodies. Duodenal biopsy confirmed total villous atrophy with intraepithelial lymphocytosis confirming the diagnosis of coeiac disease. A gluten-free diet was introduced, leading to clinical and biological improvement. Conclusion: This case illustrates that celiac disease may present solely with extra-digestive manifestations such as erythema nodosum in children.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-10-01
DOI
https://doi.org/10.5281/zenodo.17225077
Primary Topic
COVID-19 and Mental Health
Type
article
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article

ERYTHEMA NODOSUM REVEALING SILENT CELIAC DISEASE IN CHILDHOOD: A CASE REPORT

Zenodo (CERN European Organization for Nuclear Research)
COVID-19 and Mental Health
article

ERYTHEMA NODOSUM REVEALING SILENT CELIAC DISEASE IN CHILDHOOD: A CASE REPORT

article en

Abstract

Background: Erythema nodosum is the most frequent form of panniculitis, Its association with celiac disease remains uncommon, particularly in children. Case presentation: We report the case of a child presenting with recurrent erythema nodosum without gastrointestinal symptoms. Laboratory findings revealed severe iron deficiency despite prolonged oral supplementation. Serologic testing demonstrated elevated anti-transglutaminase IgA antibodies. Duodenal biopsy confirmed total villous atrophy with intraepithelial lymphocytosis confirming the diagnosis of coeiac disease. A gluten-free diet was introduced, leading to clinical and biological improvement. Conclusion: This case illustrates that celiac disease may present solely with extra-digestive manifestations such as erythema nodosum in children.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 38%
COVID-19 and Mental Health
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