EVALUATION OF ANALGESIC ACTIVITY OF MARINE SPONGE TEDANIA ANHELANS

In the present study, the methanolic extract of the marine sponge Tedania anhelans was evaluated for its phytochemical constituents and analgesic activity. Preliminary phytochemical screening revealed the presence of carbohydrates, steroids, terpenes and terpenoids. Acute toxicity studies indicated no mortality in rats at a dose of 5 g/kg body weight, suggesting a favourable safety profile. Analgesic activity was assessed using the tail immersion test in rats and the acetic acid-induced writhing test in mice, both of which demonstrated significant (p < 0.001) dose-dependent reductions in nociceptive responses. These findings suggest that Tedania anhelans possesses promising analgesic properties, supporting its potential as a source of bioactive compounds for therapeutic applications.