ROLE OF ANTIBIOTICS IN INFECTED DIABETIC FOOT ULCER IN AL-JUMHOORI TEACHING HOSPITAL

Introduction: The most common complication of Diabetes Mellitus is infection, it’s the most prevalent cause of non-traumatic amputation among all diabetes, 15% have foot infection and 28% of them require amputation. Aim: To determine the most sensitive antibiotic. Materials and Methods: This prospective observational study conducted for a period of 2 years from June 2022 to June 2024 a total of 200 swab were collected from infected diabetic foot ulcer patients in surgery department in government of Nineveh Al-Jumhoori teaching hospital in Mosul. Collected swabs were cultured and isolates we identified by microbiological techniques. Results: Total of 220 isolates were obtained from 200 swab samples. Among them 200 were Gram-negative bacilli, 12 were Gram-positive cocci and 8 were negative cocci-bacilli. Two organisms were obtained in 10 swabs culture (polyorganism). The most common isolates was Pseudomonas species 66 (30%) followed by Klebsiella species 55 (25%), Proteus species 44 (20%), Escherichia coli 33 (15%), Staphylococcus aureus 10 (4.5%) and Acinetobacter species 6 (2.7%). Majority of Gram-negative isolates (208) were sensitive to cefaperazone-sulbactum (71%), Meropenem (40%). All Gram-positive isolates (12) were sensitive to Linezolid, Amoxyclav. Conclusion: Present study confirmed the presence of multidrug resistant pathogens in diabetic foot ulcers. This knowledge of antibiotic susceptibility, patterns of isolates from wound helps in guiding clinicians for better planning of treatment with appropriate antibiotics, reducing the resistance patterns and minimizing healthcare costs.