The Role of Methionine in Neurodegenerative Diseases: A Comprehensive Review

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s lead to the destruction of nerve cells, and their prevalence is increasing due to aging. Methionine, an essential amino acid, plays a role in metabolic processes and the production of antioxidants, and its deficiency can lead to cognitive decline. However, high levels of methionine may increase the risk of neurodegenerative diseases. This article reviews the effects of methionine on neurodegenerative diseases and the importance of its balanced intake. Methionine plays an important role in human physiological processes and is involved in protein synthesis, DNA methylation and the production of antioxidants. This amino acid helps maintain oxidative balance and lipid metabolism, and its deficiency can lead to problems such as impaired growth and liver damage. In neurodegenerative diseases such as Alzheimer’s and Parkinson’s, methionine is important due to its effects on oxidative stress and mitochondrial function. In the case of Alzheimer’s, diets high in methionine are associated with an increased risk of the disease, while methionine restriction may offer potential protection. In Parkinson’s disease, methionine also acts as an antioxidant and may help maintain neuronal health. Overall, research suggests that methionine restriction may serve as an effective dietary intervention in the management of neurodegenerative diseases and in improving cognitive function.