Investigation the effect of isotretinoin on some level hormones in female rats

The aim of the study Investigation the effect of isotretinoin on serum LH,FSH, Prolactin and AMH level hormones in female rats The current study Contain 20 rats, each group containing five rats. The first group was the control group given normal saline daily by oral, while the second group was given the drug 15 mg/kg isotretinoin (Pinar et al.,2020) and the third group was given 30 mg/kg isotretinoin. The fourth group was given 30 mg/kg isotretinoin and omega-3 400mg\kg. after 30 days of treatment serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, and total and anti- Muller hormone were measured and compared. After treatment, mean serum LH,FSH,and AMH levels significantly decreased in G2 and G4, but prolactin serum levels increase. While in G4 There was a slight improvement in hormone LH,FSH,and AMH levels.