Rejuvenating the ovaries: A review of innovative strategies for fertility restoration

Modern women are delaying having children, which increases their risk of developing ovarian insufficiency. Over the course of her reproductive life, a woman's ability to procreate is mostly determined by the number of follicles in her ovaries and the quality of the oocytes that are produced within them. Advance age is a major risk factor for reducing the amount and quality of viable eggs. Thus, it is vitally critical to develop innovative methods for safely restoring ovarian function. Ovarian rejuvenation is a new term that has acquired popularity recently. This review will concentrate on knowledge gained in recent years regarding ovarian aging, potential ways of treatment, and extending the ovaries' lifespan. New treatments are being investigated, including stem cell therapies, mitochondrial enhancement therapy, and, most recently, PRP injections. In any case, further research is needed to determine the optimal dosages, minimize danger, and maximize the effectiveness of the interventions.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-09-27
DOI
https://doi.org/10.5281/zenodo.17212134
Primary Topic
Melanoma and MAPK Pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

Rejuvenating the ovaries: A review of innovative strategies for fertility restoration

Zenodo (CERN European Organization for Nuclear Research)
Melanoma and MAPK Pathways
article

Rejuvenating the ovaries: A review of innovative strategies for fertility restoration

article en

Abstract

Modern women are delaying having children, which increases their risk of developing ovarian insufficiency. Over the course of her reproductive life, a woman's ability to procreate is mostly determined by the number of follicles in her ovaries and the quality of the oocytes that are produced within them. Advance age is a major risk factor for reducing the amount and quality of viable eggs. Thus, it is vitally critical to develop innovative methods for safely restoring ovarian function. Ovarian rejuvenation is a new term that has acquired popularity recently. This review will concentrate on knowledge gained in recent years regarding ovarian aging, potential ways of treatment, and extending the ovaries' lifespan. New treatments are being investigated, including stem cell therapies, mitochondrial enhancement therapy, and, most recently, PRP injections. In any case, further research is needed to determine the optimal dosages, minimize danger, and maximize the effectiveness of the interventions.

Zenodo (CERN European Organization for Nuclear Research)
Military Hospital (PK), Chinese Medical Doctor Association (CN), Rotorua Hospital (NZ)
Openalex Percentile: Top 49%
Melanoma and MAPK Pathways
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