USING BIOIMPEDANCE ANALYSIS TO GUIDE ANTIHYPERTENSIVE THERAPY ADJUSTMENT IN PATIENTS WITH HIGH PERIPHERAL RESISTANCE

Effective treatment of hypertension remains a leading global health issue with special concern for patients with excessive peripheral resistance which is a low hanging fruit in health optimization. The use of bioimpedancemetry offers a new way to individualize antihypertensive treatment by optimizing fluid volum and vascular fluid distribution. The objective of this study was to asses the effectiveness of bioimpedancemetry in tailoring antihypertensive therapy in patients with excessive peripheral resistance. Sixty-two patients with hypertension aged 29-60 years old with a mean age of 48.75 years (30 females) were recruited for the study. Bioimpedancemetry was used to determine vascular resistance and fluid balance. Then, bioimpedancemetry was used to individualize the antihypertensive strategy and inform the treatment adjustments. The outcomes were tracked and assesed after a period of 6 months. The treatment which used bioimpedancemetry as a guide was able to decrease mean arterial blood pressure and peripheral resistance significantly more than standard treatment (p < 0.05). Women (p < 0.05) showed more improvement in some vascular resistance parameters compared to men. In addition, patients who therapy based on therapy bioimpedance data showed better therapy adherence as well as better therapy outcomes. Therapy related adverse side effects or negative outcomes were not observed. The integration of bioimpedancemetry in managing patients with hypertension and high peripheral resistance significantly enhances therapeutic outcomes by enabling personalized treatment strategies. This method holds promise for broader clinical application in hypertension management.