FORMULATION & DEVELOPMENT OF ANTIPSORIATIC GEL FOR TOPICAL DRUG DELIVERY

 FTIR spectroscopy studies confirmed that there is compatibility between drug and excipients. Gel was prepared by using Dimethyl sulfoxide, Carbopol 10NF, propylene glycol, glycerol, methyl paraben, propyl paraben and water. The Optimized formulation (F3) is more effective compared to all formulations. The Prepared Gel showed acceptable Physical properties such as pH (4.99), assay (100.9%w/w) And In vitro diffusion studies have shown 98.2% drug release in 48 hours. Formulation was loaded for stability at Accelerated condition 40°C/75%RH and 30°C/65%RH for 1,2 and 3 month. Optimized formulation (F3) has shown good stability and acceptable In vitro performance.