Impact of Ionic Strength on the Solubility, Density, Viscosity, and Conductivity of Aspirin in Aqueous Phase

ASA is an odorless, colorless to white, crystalline powder with the chemical formula C9H8O4[12]. It is a phenolic acid compound, is a metabolite of salicin, one of the oldest pain relievers derived from willow bark. At the same time, it is a precursor of a well-known drug, ASA is widely used as an intermediate for the production of many industrial compounds. In this sense, salicylic acid is one of the active ingredients in cosmetic products. The present paper reveals the impact of various salts on the physicochemical properties of Aspirin (Acetylsalicylic Acid((ASA) in aqueous solutions. The study evaluates how the addition of sodium chloride, calcium chloride magnesium chloride, and iron (III) chloride influences the solubility, density, viscosity, and degree of dissociation of ASA in aqueous solutions. These insights are crucial for optimizing pharmaceutical formulations and improving drug delivery efficiency in therapeutic applications.