Therapeutic VEGFC treatment provides protection against traumatic brain injury-driven tauopathy pathogenesis

snRNA-seq Phyton code for comparison of mild TBI PS19 mice to sham (non-injured controls) with and without VEGFC treatment. To asses gene expression differences between each of our four treatment groups (Sham+GFP, Sham+VEGFC, TBI+GFP, TBI+VEGFC) we combined the right (ipsilateral) hippocampus from 5 individual mice to yield a pooled sample of cells for each condition. The code includes files for both a global analysis of all the cells as well as a neuron specific reclustering.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-09-26
DOI
https://doi.org/10.5281/zenodo.17180219
Primary Topic
Logistics and Infrastructure Analysis
Type
article
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article

Therapeutic VEGFC treatment provides protection against traumatic brain injury-driven tauopathy pathogenesis

Zenodo (CERN European Organization for Nuclear Research)
Logistics and Infrastructure Analysis
article

Therapeutic VEGFC treatment provides protection against traumatic brain injury-driven tauopathy pathogenesis

article en

Abstract

snRNA-seq Phyton code for comparison of mild TBI PS19 mice to sham (non-injured controls) with and without VEGFC treatment. To asses gene expression differences between each of our four treatment groups (Sham+GFP, Sham+VEGFC, TBI+GFP, TBI+VEGFC) we combined the right (ipsilateral) hippocampus from 5 individual mice to yield a pooled sample of cells for each condition. The code includes files for both a global analysis of all the cells as well as a neuron specific reclustering.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 37%
Logistics and Infrastructure Analysis
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Therapeutic VEGFC treatment provides protection against traumatic brain injury-driven tauopathy pathogenesis · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS