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The study focused on the formulation and evaluation of a beta-cyclodextrin-based nanosponge cream containing Desonide for the treatment of skin diseases. Pre-formulation studies confirmed the identity and quality of Desonide through organoleptic analysis, melting point determination (214 °C), pH (3.9), and solubility testing, which showed poor water solubility but good solubility in acetone and DMSO. IR spectroscopy confirmed the presence of key functional groups. Nanosponges were successfully formulated and characterized, with F4 showing the best results in terms of smallest particle size (59.91 nm), highest entrapment efficiency (97.41%), and optimal zeta potential (-12.7 mV). SEM analysis revealed a spherical, porous morphology.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-09-24
DOI
https://doi.org/10.5281/zenodo.17192449
Primary Topic
Enzyme Structure and Function
Type
article
Field-Weighted Citation Impact
0.00
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Zenodo (CERN European Organization for Nuclear Research)
Enzyme Structure and Function
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Abstract

The study focused on the formulation and evaluation of a beta-cyclodextrin-based nanosponge cream containing Desonide for the treatment of skin diseases. Pre-formulation studies confirmed the identity and quality of Desonide through organoleptic analysis, melting point determination (214 °C), pH (3.9), and solubility testing, which showed poor water solubility but good solubility in acetone and DMSO. IR spectroscopy confirmed the presence of key functional groups. Nanosponges were successfully formulated and characterized, with F4 showing the best results in terms of smallest particle size (59.91 nm), highest entrapment efficiency (97.41%), and optimal zeta potential (-12.7 mV). SEM analysis revealed a spherical, porous morphology.

Zenodo (CERN European Organization for Nuclear Research)
Clean water and sanitation
Openalex Percentile: Top 59%
Enzyme Structure and Function
DOIOpen Access PDFOpenAlex
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