10.5281/zenodo.17189360

Introduction: Estrogen receptors (ER) and progesterone receptors (PR) are major prognostic factors in breast cancer while HER2/neu is a useful predictive factor to decide on chemotherapy like trastuzumab. They are useful for subtyping, therapeutic planning, and tailoring chemotherapy regimens of patients with breast cancer. Hence, the study was conducted to assess the hormone receptor status in breast carcinoma patients and to correlate this reactivity pattern with histologic grade, tumor stage, and lymph node metastasis. Materials and methods: This was a prospective observational study conducted for a duration of 3 years among modified radical mastectomy (MRM) specimens from 58 females diagnosed with breast carcinoma. Suitable blocks were chosen for IHC. Association between categorical variables was assessed using Chi-square test. Results: Mean age of patients was 49.34 years. Invasive Ductal Carcinoma was the most common histological diagnosis. Majority patients presented with grade II (57.69%) and stage II (58.62%). ER, PR and HER2/neu positivity was seen among 53.44%, 41.38% and 13.79% cases respectively. Conclusion: Significant association was found between ER/PR expression and HER2/neu expression with histological grade and stage of cancer. These findings underscore the importance of assessing hormone receptor and HER2/neu status as essential components in the prognostic evaluation and therapeutic planning for breast cancer patients.