D-Aspartate-Induced Fructose Elevation and Its Impact on Sperm Motility: A Systematic Review

Male infertility, particularly due to reduced sperm motility, remains a significant challenge in reproductive medicine. This review evaluates the role of D-aspartate (D-Asp), a naturally occurring amino acid, in enhancing sperm motility through fructose elevation in seminal plasma.[11] D-Aspartate is an endogenous amino acid involved in luteinizing hormone (LH) and testosterone release in humans. This study evaluated the effect of oral sodium D-aspartate supplementation on sperm quality in sub- fertile men and the resulting pregnancy rates in their partners. It to be a promising natural agent for improving sperm motility through its ability to elevate seminal fructose concentrations. However, more standardized clinical trials are needed to confirm optimal dosing, duration, and long-term effects on male fertility outcomes. Dose: 10 ml of 2.0 M sodium D-aspartate solution (equivalent to 2.66 g of D-aspartic acid neutralized with 0.46 g NaOH) Frequency: Once daily, dissolved in half a glass of water or fruit juice, taken at lunch or dinner Duration: 90 days (3 months) continuous treatment. Sixty sub-fertile patients were enrolled—30 with oligo-asthenozoospermia and 30 with asthenozoospermia. Each received a daily oral dose of sodium D-aspartate (10 ml of 2.0 M solution) for 90 days. Sperm concentration, motility, and pregnancy outcomes were assessed before and after treatment. Fructose, a key energy substrate in seminal plasma, supports ATP production and flagellar activity of spermatozoa[26]. Elevated fructose levels are associated with enhanced progressive motility and fertilizing potential, whereas reduced fructose correlates with poor motility and subfertility[25] Sodium D-aspartate supplement improves fructose level in semen. It also improves sperm concentration and motility in sub-fertile men, leading to increased pregnancy rates in their partners, without harmful side effects.